Symptoms of PK Deficiency | Know PK Deficiency
See data on the long-term impact of PK deficiency

Symptoms of PK deficiency

How does PK deficiency affect everyday life?

Explore the key terms used on this page

Signs and symptoms of PK deficiency are different for
everyone and can change over time

Common symptoms

Common symptoms
  • Debilitating fatigue
  • Exercise intolerance
  • Jaundice
  • Scleral icterus

Some symptoms are cognitive

  • Difficulty concentrating
  • Brain fog
  • Memory loss

PK deficiency and fatigue

Your doctor may not understand what you mean when you say you're tired or feeling fatigued. More vivid examples may help. Some descriptions others with PK deficiency have used with their doctors include:

  • Sometimes I’m so tired I feel like I’m 80 years old
  • Brain fog reduces my ability to do simple math

Track your daily symptoms, save reports, and share updates with your healthcare
team and others using the MyPKD App.

Additional signs and symptoms

Which of these symptoms do you have and which bother you the most? Are there any you’re just starting to notice, or that you didn’t think could be related to your PK deficiency?

Signs and Symptoms of PK deficiency in the body

Select your symptoms and download a list to share with your doctor:

Bilirubin: A substance created from hemoglobin when RBCs break down, which can cause jaundice and scleral icterus

Jaundice: Yellowing of the skin caused by high levels of bilirubin in the body

Scleral icterus: Yellowing of the whites of the eyes caused by high levels of bilirubin in the body

Cognitive difficulties: Problems associated with memory, language, thinking, and judgment


PK deficiency affects more than just the body. In a survey, people with PK deficiency reported feeling anxiety, depression, low self-esteem, and social isolation. It’s important to talk to your healthcare provider if you experience any of these mental health challenges.

Be your own advocate…find
somebody willing to listen to you.
Molly, 34
Quote from Molly, 34
Be your own advocate…find
somebody willing to listen to you.
Molly, 34

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